Thiamidol – the number one ingredient against hyperpigmentation

What is Thiamidol and how does it work?

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Thiamidol is a revolutionary and unique active ingredient that reduces dark marks and dark spots, a common skin concern. Acting at the root cause of dark marks, it works by reducing melanin production. Read this article to learn how you can use Eucerin products containing Thiamidol to make your skin more even.


What is Thiamidol?

Patented Thiamidol reduces pigment spots
Effective and fast working

Thiamidol is a patented ingredient, developed by Eucerin, which is clinically and dermatologically proven to reduce dark spots and prevent their reappearance.  

It’s the result of 10 years of research and over 50,000 tested ingredients, and you can find it as a key ingredient in many of our skincare products.


How does Thiamidol address dark marks?

A solution for more even skin.
Reducing Tyrosinase for more even skin.

Melanin is the brown pigment that determines the colour of our skin. The production of melanin in our skin depends on many different factors, such as the strength of the sun's rays and duration of sun exposure.  

Sometimes, due to hormone changes during pregnancy, inflammation, in the form of acne or due to the ageing process of the skin, our skin cells only produce more melanin in small areas and thus irregular pigmentation occurs. This is understood as hyperpigmentation, melasma or age spots.  

Pigmentation occurs when the enzyme tyrosinase converts the amino acid tyrosine into melanin. With increased activation, this enzyme can produce more melanin and the skin can appear darker in some areas. These dark marks and spots on the skin are quite common but can be distressing when noticeable. 

Thiamidol effectively reduces melanin production by blocking the enzyme tyrosinase, which converts the amino acid tyrosine into melanin. Less melanin is transported from the basal layer of the skin to the top of the skin and with that, dark spots gradually fade and are prevented from reappearing.

How efficient is Thiamidol?

First results of hyperpigmentation reduction are visible in just 12 weeks, showing a reduction of -75%.
Significant results of hyperpigmentation reduction are visible in just 12 weeks, showing a reduction of -75%.

The short answer? Very. Thiamidol is currently the most effective inhibitor of human tyrosinase, the enzyme that contributes to skin hyperpigmentation.  

In fact, first results are visible after just two weeks of regular use thanks to reduced melanocyte activity. Within 12 weeks of using Eucerin Even Pigment Perfector Dual Serum, dark mark reduction of up to 75% was shown.  

Thiamidol is a lesser-known active with a high-performance profile, revealed during extensive testing at Beiersdorf. Ultimately, the enzyme tyrosinase does not only exist in humans, but also in a lot of different animals and plants. When testing actives in the lab, it is still very common to use the enzyme found in mushrooms because of its accessibility. Until recently, all actives were tested on the mushroom enzyme, but the human enzyme is of course much more complex. 

Isolating the human enzyme for testing is more challenging because the structure of the human enzyme is also more fragile. However, Beiersdorf researchers succeeded and were the first to isolate the human enzyme and made it available for testing. This was the first step in identifying tyrosinase’s targeted structure. Out of 50,000 components tested, Thiamidol stood out for its ability to able to block the tyrosinase in small concentrations. Whereas other tyrosinase inhibitors are not effective on human enzyme because they were designed the mushroom enzyme.

How Thiamidol works for all skin types

Protection for all skin tones and types.
Suitable for all skin types.

Thiamidol is very gentle, meaning it’s great for sensitive skin. It works for skin of any ethnicity or age and is effective on all skin types and tones. 

Eucerin Even Pigment Perfector products contain Thiamidol and can be used alongside dermatological treatments such as chemical peels and laser therapies when skin is fully intact (and not wounded or open) to boost and extend results.

Use with products containing SPF coverage for increased effectiveness.
Increased effectiveness used with SPF range containing Thiamidol.

Sun exposure is the number one cause of hyperpigmentation and triggers the production of melanin, a natural pigment that gives colour to skin. Thus, exposure to sunlight, hormonal influences and ageing can cause an increase in melanin production and trigger hyperpigmentation. Repeated and regular sun exposure can cause pigment spots to become visible at a younger age. But constant and daily sun protection will prevent new spots forming. 

Not only this, but it also improves Thiamidol’s efficacy. For example, the Eucerin Even Pigment Perfector Dual Serum is up to 2.5 times more effective in reducing dark spots when used with Eucerin Even Pigment Perfector Day SPF 30.

The efficacy is also increased because each of the aforementioned products contain Thiamidol. However, products containing Thiamidol should only be applied a maximum of four times per day.

Using Thiamidol against post-acne marks

Clinically proven to visibly reduce post-acne marks by up to 80%<1>object</sup> and blemishes by up to 90%<sup>2</sup>. Visibly improves pores by up to 71%<sup>2</sup>.  First visible results in 2 weeks.       1, 2: Gallinger J. et al, Effective solution to reduce both blemishes and acne-related post-inflammatory hyperpigmentation with a novel skin care formulation tailored for acne-prone skin containing the tyrosinase inhibitor Thiamidol, EADV 2021.
Clinically proven to visibly reduce post-acne marks by up to 80%1 and blemishes by up to 90%2. Visibly improves pores by up to 71%2.  First visible results in 2 weeks.

Post-inflammatory hyperpigmentation is what happens when skin is inflamed or injured, for example, as a result of acne, and the impact area is left darkened and hyperpigmented despite having otherwise healed.  

Eucerin’s DERMOPURIFYER range also contains a product formulated to reduce post-acne marks and prevent the appearance of blemishes. Eucerin DERMOPURIFYER Triple Effect Serum includes active ingredients such as salicylic acid and Licochalcone A that work against acne. 

The Triple Effect Serum has enhanced efficacy when used together with the Eucerin DermoPurifyer Protective Fluid SPF 30. In fact, respondents in our studies report that the products not only improved their lives and provided relief, but also have the highest efficacy against post-acne marks of any products they have ever tried. “The combination beats post-acne marks,” say 95% of users*. 

*Product in use study with 100 volunteers. Eight weeks of regular usage twice a day.

Using Thiamidol against age spots

Reduction of hyperpigmentation after 12 weeks of using products containing Thiamidol is visible, as a pigment spot is faded.
Reduction of hyperpigmentation after 12 weeks of using products containing Thiamidol is visible, as a pigment spot is faded.

Often appearing on the face, hands and other parts of the body exposed to the sun, age spots are small areas of discolouration (hyperpigmentation) visible on the skin.  They are most common in people over the age of 40 (hence the name) but they can occur earlier. 

Eucerin Hyaluron-Filler + Elasticity 3D Serum is a light and moisturising anti-aging serum that has been specially formulated for mature skin. It contains high and low molecular Hyaluronic Acid and Arctiin to plump up deep wrinkles and improve skin elasticity, as well as Thiamidol for actively reducing age spots




Leaves skin feeling rejuvenated


Improves overall quality


Leaves the skin feeling soft and silky smooth


Provides a nourishing skin feeling

User survey n=130, 50-65 years with a high incidence of age spots on the face using blinded test product for four weeks.


As age spots also occur on the hands due to their frequent sun exposure, Eucerin Age Spot Correcting Hand Cream is formulated to specifically address the skin in this area.





Leaves skin feeling rejuvenated


Gives me visibly more beautiful hands


Leaves the skin feeling soft and silky smooth


Improves overall skin quality


Improves skin firmness and elasticity


Leaves the skin feeling soft and silky smooth

* User survey after two weeks. Product in use test, n=130 (50-65y) with a high incidence of age spots on hands using blinded test product for two weeks at least daily.

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Pioneers in skincare

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Recommended by dermatologists

We work together with leading dermatologist and pharmacist partners around the world to create innovative and effective skincare products they can trust and recommend.

Committed to innovation

For over 100 years, we have dedicated ourselves to researching and innovating in the field of skin science. We believe in creating active ingredients and soothing formulas with high tolerability that work to help you live your life better each day.

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