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About

A revolutionary anti-ageing serum with Epicelline® that helps to reverse and prevent signs of epigenetic changes allowing one's skin to look younger than its age and reverses 10 signs of ageing. Visible results in 4 weeks (Product-in-use test with 160 women over 4 weeks).
NART: 99122-09924-00

Read more about our product

Our breakthrough anti-age innovation. Skin aging is accelerated by lifestyle and environmental factors that change the skin’s epigenetic patterns. This means that youth genes are deactivated, leading to visible signs of ageing. After 15 years of epigenetic research, Eucerin has discovered how to reactivate these youth genes based on a patented Age Clock Technology: Epicelline® reactivates the skin’s youth genes at the root and allows skin cells to act younger. This mechanism makes the skin look younger than its age and reverses 10 signs of aging, visibly leading to: Firmness, Lifting effect, Wrinkle reduction, Fine line reduction, Enhanced Contours, Hydration, Radiance Rejuvenation, Evenness and Smoothness Disclaimer: Clinical study over 2 and 4 weeks with 43 volunteers respectively. Product-in-use test over 4 weeks over 160 volunteers.

Main findings

*Product-in-use test with 160 women over 4 weeks.
98% confirm:
reduced wrinkles
99% confirm:
firmer-looking skin
98% confirm:
younger-looking skin
98% confirm:
rejuvenates skin
99% confirm:
provides healthy-looking skin
97% confirm:
skin feels immediately hydrated

Clinical Formula

Hyaluronic acid

Hyaluronic Acid is a skin-own humectant and filling substance, synthesized by epidermal keratinocytes and dermal fibroblasts. It plays a crucial role in skin hydration and volume. Natural levels of Hyaluronic Acid decrease with age leading to the formation and deepening of wrinkles. Two key benefits are:

  • Wrinkle Reduction: High molecular weight hyaluronic acid (~2,000 kDa) binds and retains high amounts of water, keeping the skin firm and well moisturized. This helps to smooth fine lines and wrinkles in the upper skin layers.
  • Deep Skin Rejuvenation: Low molecular weight hyaluronic acid (~52 kDa) penetrates deeper into the epidermis, stimulating skin’s own hyaluronan synthesis and promoting cell proliferation.
Learn More
Glycine Saponin

Glycine Saponin is a bioactive compound derived from Soybean Germ (Glycine max), containing isoflavones and saponins. It is a potent antioxidant that plays a key role in maintaining skin structure and elasticity by stimulating essential extracellular matrix (ECM) components. Key benefits are:

  • Hyaluronic Acid Stimulation: Promotes the biosynthesis of skin’s own hyaluronic acid to enhance moisture retention and plumpness.
  • Collagen & Elastin Boost: Supports the production of collagen and elastin to strengthen the skin’s structure and elasticity.
  • Antioxidant Protection: Helps neutralize free radicals, protecting the skin from oxidative stress.
Learn More
Enoxolone

Glycyrrhetinic Acid, also called Enoxolone, is derived from the roots of Glycyrrhiza glabra (licorice plant) and is traditionally used in Chinese medicine. Key benefits are:

  • Protection of Skin Structure: Preserves hyaluronic acid and elastin by inhibiting hyaluronidase and elastase, helping to maintain skin elasticity and hydration.
  • DNA Repair Support: Aids the skin’s natural repair mechanisms against UV-induced DNA damage.
Learn More
Epicelline

Enoxolone, also known as Glycyrrhetinic Acid is derived from the roots of Chinese licorice plants. It inhibits the Hyaluronic Acid degradating enzyme Hyaluronidase (HYAL1) and therefore the degradation of skin‘s own Hyaluronic Acid by more than 50%.

Learn More
Hyaluronic acid

Hyaluronic Acid is a skin-own humectant and filling substance, synthesized by epidermal keratinocytes and dermal fibroblasts. It plays a crucial role in skin hydration and volume. Natural levels of Hyaluronic Acid decrease with age leading to the formation and deepening of wrinkles. Two key benefits are:

  • Wrinkle Reduction: High molecular weight hyaluronic acid (~2,000 kDa) binds and retains high amounts of water, keeping the skin firm and well moisturized. This helps to smooth fine lines and wrinkles in the upper skin layers.
  • Deep Skin Rejuvenation: Low molecular weight hyaluronic acid (~52 kDa) penetrates deeper into the epidermis, stimulating skin’s own hyaluronan synthesis and promoting cell proliferation.
Learn More
Glycine Saponin

Glycine Saponin is a bioactive compound derived from Soybean Germ (Glycine max), containing isoflavones and saponins. It is a potent antioxidant that plays a key role in maintaining skin structure and elasticity by stimulating essential extracellular matrix (ECM) components. Key benefits are:

  • Hyaluronic Acid Stimulation: Promotes the biosynthesis of skin’s own hyaluronic acid to enhance moisture retention and plumpness.
  • Collagen & Elastin Boost: Supports the production of collagen and elastin to strengthen the skin’s structure and elasticity.
  • Antioxidant Protection: Helps neutralize free radicals, protecting the skin from oxidative stress.
Learn More
Enoxolone

Glycyrrhetinic Acid, also called Enoxolone, is derived from the roots of Glycyrrhiza glabra (licorice plant) and is traditionally used in Chinese medicine. Key benefits are:

  • Protection of Skin Structure: Preserves hyaluronic acid and elastin by inhibiting hyaluronidase and elastase, helping to maintain skin elasticity and hydration.
  • DNA Repair Support: Aids the skin’s natural repair mechanisms against UV-induced DNA damage.
Learn More
Epicelline

Enoxolone, also known as Glycyrrhetinic Acid is derived from the roots of Chinese licorice plants. It inhibits the Hyaluronic Acid degradating enzyme Hyaluronidase (HYAL1) and therefore the degradation of skin‘s own Hyaluronic Acid by more than 50%.

Learn More
Hyaluronic acid

Hyaluronic Acid is a skin-own humectant and filling substance, synthesized by epidermal keratinocytes and dermal fibroblasts. It plays a crucial role in skin hydration and volume. Natural levels of Hyaluronic Acid decrease with age leading to the formation and deepening of wrinkles. Two key benefits are:

  • Wrinkle Reduction: High molecular weight hyaluronic acid (~2,000 kDa) binds and retains high amounts of water, keeping the skin firm and well moisturized. This helps to smooth fine lines and wrinkles in the upper skin layers.
  • Deep Skin Rejuvenation: Low molecular weight hyaluronic acid (~52 kDa) penetrates deeper into the epidermis, stimulating skin’s own hyaluronan synthesis and promoting cell proliferation.
Learn More
Glycine Saponin

Glycine Saponin is a bioactive compound derived from Soybean Germ (Glycine max), containing isoflavones and saponins. It is a potent antioxidant that plays a key role in maintaining skin structure and elasticity by stimulating essential extracellular matrix (ECM) components. Key benefits are:

  • Hyaluronic Acid Stimulation: Promotes the biosynthesis of skin’s own hyaluronic acid to enhance moisture retention and plumpness.
  • Collagen & Elastin Boost: Supports the production of collagen and elastin to strengthen the skin’s structure and elasticity.
  • Antioxidant Protection: Helps neutralize free radicals, protecting the skin from oxidative stress.
Learn More
Enoxolone

Glycyrrhetinic Acid, also called Enoxolone, is derived from the roots of Glycyrrhiza glabra (licorice plant) and is traditionally used in Chinese medicine. Key benefits are:

  • Protection of Skin Structure: Preserves hyaluronic acid and elastin by inhibiting hyaluronidase and elastase, helping to maintain skin elasticity and hydration.
  • DNA Repair Support: Aids the skin’s natural repair mechanisms against UV-induced DNA damage.
Learn More
View all

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4,5
from 160 Reviews
Write a review
    2025/04/08
    A lovely serum
    [This review was collected as part of a promotion.] I have enjoyed using Eucerin Hyaluron-Filler Epigenetic Serum. The texture is lightweight and absorbs rapidly without leaving any residue. It provides a lovely boost of hydration to my skin, making it feel smoother and revitalized. I also appreciate how well it layers under moisturizer and makeup. Overall, it has been a wonderful enhancement to my skincare routine! As for the packaging, the glass bottle feels premium and looks stunning. The fragrance is subtle and fresh, not at all overwhelming, which I truly value in skincare products.
    emmac298_8556
    2025/03/07
    Beautiful serum
    [This review was collected as part of a promotion.] Beautiful product. Does what it says I have enjoyed using this and noticed a difference in my skin. It's more hydrated and I look less tired. The bottle is easy to use and looks very stylish and expensive
    amberm761_9337
    2025/03/05
    Stunning serum 💖
    [This review was collected as part of a promotion.] I’ve been using the Eucerin Hyaluron-Filler Epigenetic Serum, and I really like how it feels on my skin. The texture is lightweight and absorbs quickly without any stickiness. It gives my skin a nice boost of hydration, making it feel smoother and more refreshed. I also love that it layers well under moisturizer and makeup. So far, a really nice addition to my skincare routine! Packaging – the glass bottle feels high-quality and looks beautiful. The scent is very light and fresh, not overpowering at all, which I really appreciate in skincare products.
    bee_bee_1765
See all
*The authenticity of the reviews is not verified
Hyaluron-Filler + 3x Effect

Hyaluron-Filler Epicelline® Serum

  • 4,5
    160 reviews
Skin concerns
Ageing skin
Key Benefits
  • REVERSES 10 SIGNS OF AGEING: The Eucerin Hyaluron-Filler Epicelline® Serum reverses 10 signs of skin ageing visibly and makes the skin look younger than its age in 4 weeks.
  • WITH EPICELLINE® AND DEVELOPED USING PATENTED AGE CLOCK TECHNOLOGY: The serum contains the powerful active ingredient Epicelline®, which helps to reverse and prevent signs of epigenetic changes allowing one's skin to look younger than its age. It also contains micro and macro Hyaluronic acid, Saponin and Enoxolone.
  • MAKES YOU LOOK YOUNGER THAN YOUR AGE: The serum reverses 10 signs of skin ageing visibly, leading to: Firmness, Lifting effect, Wrinkle reduction, Fine line reduction, Enhanced Contours, Hydration, Radiance, Rejuvenation, Evenness and Smoothness
  • VISIBLE RESULTS IN 4 WEEKS: Clinical studies of the Eucerin Hyaluron-Filler Epicelline® Serum confirm visible results in 4 weeks of using the serum.
  • CLINICALLY AND DERMATOLOGICALLY PROVEN: This product is clinically and dermatologically proven to show very good skin tolerability and efficacy for all skin types.
  • COMPLETE ROUTINE FOR AGEING SKIN: For best results, apply the serum as first step of morning an evening skin care routine. Follow up with Eucerin Hyaluron-Filler Day or Night Care.
Read More
Key Ingredients

Epicelline, Hyaluronic acid, Glycine Saponin

Learn More
Size
30 ml