Sustainability & Environment

We take responsibility. For your skin. And our planet.

Learn more about our sustainability program

Foldingbox made of FSC certified paper

About

A clinically tested epigenetic anti-ageing serum based on patented Age Clock Technology with highly concentrated active ingredient Epicelline® proven to visibly reverse 10 signs of aging* for visibly younger skin and activate skin longevity. *Clinical study with volunteers applying the product twice daily over 8 weeks.
NART: 99122-09924-28

Read more about our product

Our breakthrough anti-age innovation! The Hyaluron-Filler +Longevity Epicelline® Serum is formulated with highly concentrated Epicelline® to visibly reverse signs of skin ageing. Skin ageing is accelerated by lifestyle and environmental factors that change the skin’s epigenetic patterns. This means that youth genes are deactivated, leading to visible signs of ageing. After 17 years of epigenetic research, Eucerin has discovered how to reactivate these youth genes based on a patented Age Clock Technology: Eucerin Hyaluron-Filler + Longevity Epicelline Serum is an ultra-light anti-aging face serum that helps visibly reduce signs of skin ageing while delivering deep hydration for a younger-looking appearance. Powered by Epicelline, a dermatologist-recommended active inspired by epigenetic skin science, the formula helps reactivate a youthful-looking appearance. Visible improvements can be seen in four weeks, with 98% confirming younger-looking skin**. Enriched with Hyaluronic Acid and Glycine Saponin, the serum deeply hydrates the face while helping visibly plump wrinkles and fine lines for smoother, firmer-looking skin. The lightweight texture absorbs quickly without leaving a sticky or greasy residue. Suitable for all skin types and skin tones, the formula is clinically and dermatologically proven.

How to Use

Apply the serum as the first step in the morning and evening. Combine with the Eucerin Epigenetic Day and Night Care for advanced efficacy with 3x power.

Main findings

* Skin longevity targets the visible signs of aging to support the skin's natural renewal process for younger-looking skin. ** Product-in-use test over 4 weeks.
100%
Confirm deep skin rejuvenation*
98%
Confirm reduced wrinkles**
98%
Confirm younger-looking skin**
100%
Confirm: The best skin I ever had*
100%
Confirm: reverses signs of aging*

Clinical Formula

Hyaluronic acid

Hyaluronic Acid is a skin-own humectant and filling substance, synthesized by epidermal keratinocytes and dermal fibroblasts. It plays a crucial role in skin hydration and volume. Natural levels of Hyaluronic Acid decrease with age leading to the formation and deepening of wrinkles. Two key benefits are:

  • Wrinkle Reduction: High molecular weight hyaluronic acid (~2,000 kDa) binds and retains high amounts of water, keeping the skin firm and well moisturized. This helps to smooth fine lines and wrinkles in the upper skin layers.
  • Deep Skin Rejuvenation: Low molecular weight hyaluronic acid (~52 kDa) penetrates deeper into the epidermis, stimulating skin’s own hyaluronan synthesis and promoting cell proliferation.
Learn More
Glycine Saponin

Glycine Saponin is a bioactive compound derived from Soybean Germ (Glycine max), containing isoflavones and saponins. It is a potent antioxidant that plays a key role in maintaining skin structure and elasticity by stimulating essential extracellular matrix (ECM) components. Key benefits are:

  • Hyaluronic Acid Stimulation: Promotes the biosynthesis of skin’s own hyaluronic acid to enhance moisture retention and plumpness.
  • Collagen & Elastin Boost: Supports the production of collagen and elastin to strengthen the skin’s structure and elasticity.
  • Antioxidant Protection: Helps neutralize free radicals, protecting the skin from oxidative stress.
Learn More
Enoxolone

Glycyrrhetinic Acid, also called Enoxolone, is derived from the roots of Glycyrrhiza glabra (licorice plant) and is traditionally used in Chinese medicine. Key benefits are:

  • Protection of Skin Structure: Preserves hyaluronic acid and elastin by inhibiting hyaluronidase and elastase, helping to maintain skin elasticity and hydration.
  • DNA Repair Support: Aids the skin’s natural repair mechanisms against UV-induced DNA damage.
Learn More
Hyaluronic acid

Hyaluronic Acid is a skin-own humectant and filling substance, synthesized by epidermal keratinocytes and dermal fibroblasts. It plays a crucial role in skin hydration and volume. Natural levels of Hyaluronic Acid decrease with age leading to the formation and deepening of wrinkles. Two key benefits are:

  • Wrinkle Reduction: High molecular weight hyaluronic acid (~2,000 kDa) binds and retains high amounts of water, keeping the skin firm and well moisturized. This helps to smooth fine lines and wrinkles in the upper skin layers.
  • Deep Skin Rejuvenation: Low molecular weight hyaluronic acid (~52 kDa) penetrates deeper into the epidermis, stimulating skin’s own hyaluronan synthesis and promoting cell proliferation.
Learn More
Glycine Saponin

Glycine Saponin is a bioactive compound derived from Soybean Germ (Glycine max), containing isoflavones and saponins. It is a potent antioxidant that plays a key role in maintaining skin structure and elasticity by stimulating essential extracellular matrix (ECM) components. Key benefits are:

  • Hyaluronic Acid Stimulation: Promotes the biosynthesis of skin’s own hyaluronic acid to enhance moisture retention and plumpness.
  • Collagen & Elastin Boost: Supports the production of collagen and elastin to strengthen the skin’s structure and elasticity.
  • Antioxidant Protection: Helps neutralize free radicals, protecting the skin from oxidative stress.
Learn More
Enoxolone

Glycyrrhetinic Acid, also called Enoxolone, is derived from the roots of Glycyrrhiza glabra (licorice plant) and is traditionally used in Chinese medicine. Key benefits are:

  • Protection of Skin Structure: Preserves hyaluronic acid and elastin by inhibiting hyaluronidase and elastase, helping to maintain skin elasticity and hydration.
  • DNA Repair Support: Aids the skin’s natural repair mechanisms against UV-induced DNA damage.
Learn More
Hyaluronic acid

Hyaluronic Acid is a skin-own humectant and filling substance, synthesized by epidermal keratinocytes and dermal fibroblasts. It plays a crucial role in skin hydration and volume. Natural levels of Hyaluronic Acid decrease with age leading to the formation and deepening of wrinkles. Two key benefits are:

  • Wrinkle Reduction: High molecular weight hyaluronic acid (~2,000 kDa) binds and retains high amounts of water, keeping the skin firm and well moisturized. This helps to smooth fine lines and wrinkles in the upper skin layers.
  • Deep Skin Rejuvenation: Low molecular weight hyaluronic acid (~52 kDa) penetrates deeper into the epidermis, stimulating skin’s own hyaluronan synthesis and promoting cell proliferation.
Learn More
Glycine Saponin

Glycine Saponin is a bioactive compound derived from Soybean Germ (Glycine max), containing isoflavones and saponins. It is a potent antioxidant that plays a key role in maintaining skin structure and elasticity by stimulating essential extracellular matrix (ECM) components. Key benefits are:

  • Hyaluronic Acid Stimulation: Promotes the biosynthesis of skin’s own hyaluronic acid to enhance moisture retention and plumpness.
  • Collagen & Elastin Boost: Supports the production of collagen and elastin to strengthen the skin’s structure and elasticity.
  • Antioxidant Protection: Helps neutralize free radicals, protecting the skin from oxidative stress.
Learn More
Enoxolone

Glycyrrhetinic Acid, also called Enoxolone, is derived from the roots of Glycyrrhiza glabra (licorice plant) and is traditionally used in Chinese medicine. Key benefits are:

  • Protection of Skin Structure: Preserves hyaluronic acid and elastin by inhibiting hyaluronidase and elastase, helping to maintain skin elasticity and hydration.
  • DNA Repair Support: Aids the skin’s natural repair mechanisms against UV-induced DNA damage.
Learn More
View all

You may also like

New

hyaluron-filler-plus-longevity

Hyaluron-Filler +Longevity Epicelline Night Care

NewSPF 30
New

hyaluron-filler-plus-longevity

Hyaluron-Filler +Longevity Epicelline Night Care

NewSPF 30
New

hyaluron-filler-plus-longevity

Hyaluron-Filler +Longevity Epicelline Night Care

NewSPF 30

Read related articles

Part 4: Safety and efficacy

How can Eucerin guarantee a safe and tolerable product? Find out here.

5 min read
Ageing skin

Wrinkles

What can I do about fine lines and deep wrinkles on my forehead and around my mouth and eyes?

6 min read
Ageing skin

Loss of Volume

What can I do to get back my youthful look?

7 min read
Eucerin Elasticity Filler Range for anti-aging
Ageing skin

BEHIND THE SCIENCE

Eucerin Hyaluron-Filler + Elasticity plumps up deep wrinkles and improves elasticity

5 min read
Ageing skin

BEHIND THE SCIENCE

The clinical study of Hyaluron-Filler with results, that are truly unique to the industry

7 min read
Ageing skin

Behind the science

Eucerin Hyaluron-Filler + Volume-Lift plumps up deep wrinkles and redefines facial contours for a lifting effect.

3 min read

Part 4: Safety and efficacy

How can Eucerin guarantee a safe and tolerable product? Find out here.

5 min read
Ageing skin

Wrinkles

What can I do about fine lines and deep wrinkles on my forehead and around my mouth and eyes?

6 min read
Ageing skin

Loss of Volume

What can I do to get back my youthful look?

7 min read
Eucerin Elasticity Filler Range for anti-aging
Ageing skin

BEHIND THE SCIENCE

Eucerin Hyaluron-Filler + Elasticity plumps up deep wrinkles and improves elasticity

5 min read
Ageing skin

BEHIND THE SCIENCE

The clinical study of Hyaluron-Filler with results, that are truly unique to the industry

7 min read
Ageing skin

Behind the science

Eucerin Hyaluron-Filler + Volume-Lift plumps up deep wrinkles and redefines facial contours for a lifting effect.

3 min read

Part 4: Safety and efficacy

How can Eucerin guarantee a safe and tolerable product? Find out here.

5 min read
Ageing skin

Wrinkles

What can I do about fine lines and deep wrinkles on my forehead and around my mouth and eyes?

6 min read
Ageing skin

Loss of Volume

What can I do to get back my youthful look?

7 min read

hyaluron-filler-plus-longevity

Eucerin Hyaluron-Filler +Longevity Epicelline Day Care SPF30

hyaluron-filler-plus-longevity

Eucerin Hyaluron-Filler +Longevity Epicelline Day Care SPF30

hyaluron-filler-plus-longevity

Eucerin Hyaluron-Filler +Longevity Epicelline Day Care SPF30

4,5
from 160 Reviews
Write a review
    2025/04/08
    A lovely serum
    [This review was collected as part of a promotion.] I have enjoyed using Eucerin Hyaluron-Filler Epigenetic Serum. The texture is lightweight and absorbs rapidly without leaving any residue. It provides a lovely boost of hydration to my skin, making it feel smoother and revitalized. I also appreciate how well it layers under moisturizer and makeup. Overall, it has been a wonderful enhancement to my skincare routine! As for the packaging, the glass bottle feels premium and looks stunning. The fragrance is subtle and fresh, not at all overwhelming, which I truly value in skincare products.
    emmac298_8556
    Originally posted on eucerin.co.uk
    2025/03/07
    Beautiful serum
    [This review was collected as part of a promotion.] Beautiful product. Does what it says I have enjoyed using this and noticed a difference in my skin. It's more hydrated and I look less tired. The bottle is easy to use and looks very stylish and expensive
    amberm761_9337
    Originally posted on eucerin.co.uk
    2025/03/05
    Stunning serum 💖
    [This review was collected as part of a promotion.] I’ve been using the Eucerin Hyaluron-Filler Epigenetic Serum, and I really like how it feels on my skin. The texture is lightweight and absorbs quickly without any stickiness. It gives my skin a nice boost of hydration, making it feel smoother and more refreshed. I also love that it layers well under moisturizer and makeup. So far, a really nice addition to my skincare routine! Packaging – the glass bottle feels high-quality and looks beautiful. The scent is very light and fresh, not overpowering at all, which I really appreciate in skincare products.
    bee_bee_1765
    Originally posted on eucerin.co.uk
See all
*The authenticity of the reviews is not verified
hyaluron-filler-plus-longevity

Hyaluron-Filler +Longevity Epicelline Serum

  • 4,5
    160 reviews
Skin concerns
Ageing skin
Key Benefits
  • EPICELLINE LONGEVITY ANTI-AGING ACTIVE: Epicelline is the No.1 choice of Dermatologists for skin longevity* and helps reactivate a youthful-looking appearance by visibly reducing the signs of skin aging.
  • VISIBLE RESULTS IN 4 WEEKS: 98% confirm younger-looking skin after using the serum, with visible improvements in wrinkles and overall skin appearance in just 4 weeks**
  • HYALURONIC ACID WRINKLE FILLING: Formulated with long and short chain Hyaluronic Acid to deeply hydrate the face while helping visibly plump wrinkles and fine lines.
  • LIGHTWEIGHT FACE SERUM: Ultra-light, fast-absorbing formula delivers intensive hydration without feeling greasy or sticky, making it suitable for daily use
  • SUITABLE FOR ALL SKIN TYPES AND TONES: Clinically and dermatologically proven anti-aging face serum suitable for all skin types and skin tones
Read More
Key Ingredients

Dihydromyricetin (Epicelline®), Hyaluronic acid, Glycine Saponin

Learn More
Size
30 ml